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Evidence for Rosettes as an Unrecognized Stage in the Life Cycle of Leishmania Parasites

12 Aug 2010

Abstract excerpt

Leishmania parasites, which afflict 12 million people in 88 countries, exist as promastigotes transmitted by insect vectors and as amastigotes residing in mammalian macrophages. Promastigote cells arranged in rosettes have also been described but universally disregarded as a distinct stage in the life cycle. We present evidence that only rosettes of Leishmania major promastigotes express cell surface...

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PMID: 20707828
DOI: 10.1111/j.1550-7408.2010.00496.x

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