Article
A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.
The Journal of clinical investigation - 1 Feb 1998
Mitchell B D, Blangero J, Comuzzie A G, Almasy L A, Shuldiner A R, Silver K, Stern M P, MacCluer J W, Hixson J E
Abstract excerpt
The beta3 adrenergic receptor, located on chromosome 8, is a regulator of energy expenditure and lipolysis. A missense mutation in this gene, characterized by the replacement of tryptophan by arginine at codon 64 (Trp64Arg), is associated with obesity in some studies. We examined the effect of this variant on obesity in Mexican Americans, using a paired sibling design to minimize variability due to genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.