Article
The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Dec 1997
Biery A J, Ebbesson S O, Shuldiner A R, Boyer B B
Abstract excerpt
OBJECTIVE: A polymorphism in the beta 3-adrenergic receptor (beta 3-AR) has been described and consists of an amino acid substitution at position 64 where tryptophan is replaced by arginine (Arg allele). This polymorphism appears to be a modest contributor to obesity and non-insulin dependent diabetes mellitus (NIDDM), and may be dependent on gender, gene dosage, ethnic background and environmental factors. We...
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