Article
Cloning, characterization and identification of the gene encoding phosphatidylinositol 4-kinase.
Cellular and molecular biology (Noisy-le-Grand, France) - 1 Nov 1997
Pramanik A, Garcia E, Ospina R, Powell M, Martinez M, Alejo W, McKoy J, Moore C W
Abstract excerpt
The vast majority of AIDS-related deaths are associated with opportunistic infections. For fungal infections, there are few effective antifungals, particularly for systemic use. The discovery that very low doses of the bleomycin family of anticancer chemical congeners compromise the integrity of fungal cell walls led to our approach to identify genes that complement-cell wall defects, and develop methods to...
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