Article
Preimplantation diagnosis of single gene disorders by two-step oocyte genetic analysis using first and second polar body.
Biochemical and molecular medicine - 1 Dec 1997
Verlinsky Y, Rechitsky S, Cieslak J, Ivakhnenko V, Wolf G, Lifchez A, Kaplan B, Moise J, Walle J, White M, Ginsberg N, Strom C, Kuliev A
Abstract excerpt
Previous work on preimplantation genetic diagnosis (PGD) of single gene disorders by the first polar body (IPB) analysis has demonstrated that the genotype of a considerable number of embryos resulting from heterozygous oocytes cannot be predicted without testing their second PB (IIPB). To overco...
Topics
- Alleles
- DNA
- Embryo, Mammalian
- Female
- Fertilization in Vitro
- Follow-Up Studies
- Genetic Diseases, Inborn
- Genotype
- Humans
- Meiosis
- Oocytes
- Polymerase Chain Reaction
- Predictive Value of Tests
- Preimplantation Diagnosis