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Polar body-based preimplantation genetic diagnosis for Mendelian disorders

14 Feb 2011

Abstract excerpt

Introduced >20 years ago, the use of polar bodies (PBs), involving sequential removal and genetic analysis of the first (PB1) and second (PB2) PB, provides the option for pre-embryonic diagnosis, when the objection to the embryo biopsy procedures makes preimplantation genetic diagnosis (PGD) non-applicable. PB-based approach has presently been utilized in PGD for genetic and chromosomal disorders, applied either...

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PMID: 21320873
DOI: 10.1093/molehr/gar012

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