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Article

Factor VIII gene mutations found by a comparative study of SSCP, DGGE and CMC and their analysis on a molecular model of factor VIII protein.

Human genetics - 1 Dec 1997

Schwaab R, Oldenburg J, Lalloz M R, Schwaab U, Pemberton S, Hanfland P, Brackmann H H, Tuddenham E G, Michaelides K

Abstract excerpt

Screening of the factor VIII (FVIII) gene which spans 186 kb and codes for 26 exons, was originally hampered by its size but is now feasible because rapid DNA scanning methodologies have been developed. The present study for the first time directly compares the three most widely applied screening methods, denaturing gradient gel electrophoresis (DGGE), single-stranded conformational polymorphism (SSCP) and...

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PMID: 9439662
DOI: 10.1007/s004390050636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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