Article
Determinants of the factor IX mutational spectrum in haemophilia B: an analysis of missense mutations using a multi-domain molecular model of the activated protein.
Human genetics - 1 Dec 1994
Wacey A I, Krawczak M, Kakkar V V, Cooper D N
Abstract excerpt
A multi-domain molecular model of factor IXa was constructed by comparative methods. The quaternary structure of the protein was assembled by docking individual domains through consideration of their shape complementarity, polaric properties and the location of cross-reacting material positive/ne...
Topics
- Factor IX
- Hemophilia B
- Humans
- Models, Genetic
- Models, Molecular
- Mutation
- Protein Conformation