Practical considerations of genetic rodent models for neurodegenerative diseases.

doi:10.1007/978-1-61779-328-8_12

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Article

Practical considerations of genetic rodent models for neurodegenerative diseases.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Geghman Kindiya, Li Chenjian

Abstract excerpt

In recent years, the rapid advances in human genetics have identified many genes that are responsible for inherited diseases. In the effort to understand pathogenic pathways and develop therapeutics, researchers have developed genetic animal models as critical tools for the purpose of neurodegenerative disease study. In this overview chapter, we do not intend to cover all the transgenic models for particular...

Topics

Animals
Disease Models, Animal
Gene Knockout Techniques
Gene Transfer Techniques
Mutation
Neurodegenerative Diseases
Proteins

Source

Open in PubMed

Identifiers

PMID: 21913101
DOI: 10.1007/978-1-61779-328-8_12

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