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Article

Role of HOX genes in human development.

Current opinion in pediatrics - 1 Dec 1997

Innis J W

Abstract excerpt

Hox genes specify developmental boundaries and determine cell fate during morphogenesis. Recently, two human syndromes, synpolydactyly and hand-foot-genital were shown to result from mutations in HOX genes. Both disorders affect digital arch structures and can involve genitourinary malformations. These studies confirm the critical role of these highly conserved transcription factors in the specification of growth...

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Identifiers

PMID: 9425595
DOI: 10.1097/00008480-199712000-00011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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