Functional dissection of YA, an essential, developmentally regulated nuclear lamina protein in Drosophila melanogaster.

Abstract excerpt

The Drosophila YA protein is a nuclear lamina component whose function is essential to initiate embryonic development. To identify regions of YA required for its action in its normal cellular context, we made targeted mutations in the YA protein and tested their consequences in flies and embryos in vivo. We found that critical amino acids are distributed along the length of the YA molecule, with functionally...

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