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Article

The effects of variable mutation rates across sites on the phylogenetic estimation of effective population size or mutation rate of DNA sequences.

Genetics - 1 Nov 1996

Deng H W, Fu Y X

Abstract excerpt

Multiple hits at some sites of human mitochondrial DNA sequences suggest that the commonly assumed infinite-sites model can be violated. Under the neutral Wright-Fisher model without recombination and population subdivision, we investigated, by computer simulations, the effect of multiple hits on the estimation of the essential parameter theta = 4Nmu by FU's UPBLUE procedure. We found that with moderate mutation...

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Identifiers

PMID: 8913767
DOI: 10.1093/genetics/144.3.1271
PMCID: PMC1207618

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Source receipt: pubmed, retrieved 7 Sept 2026.

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