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Article

Telomerase activity in the normal and neoplastic rat mammary gland.

Cancer research - 15 Dec 1997

Varon D, Jiang C, Hedican C, Dome J S, Umbricht C B, Carey L A, Thompson H J, Sukumar S

Abstract excerpt

The 1-methyl-1-nitrosourea-induced rat mammary tumor model system is well studied, reproducible, and widely used. We have investigated whether these tumors possess higher telomerase activity than normal mammary tissue. Using the telomeric repeat amplification protocol assay, we found significantly higher telomerase activity in 36 mammary carcinomas than in 72 mammary glands of virgin rats. The level of telomerase...

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PMID: 9407974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels.Semantic proximity Read ↗

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