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Article

Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase.

Molecular biology of the cell - 1 Dec 1997

Fiorentino D F, Crabtree G R

Abstract excerpt

The TOR proteins, originally identified as targets of the immunosuppressant rapamycin, contain an ATM-like "lipid kinase" domain and are required for early G1 progression in eukaryotes. Using a screen to identify Saccharomyces cerevisiae mutants requiring overexpression of Tor1p for viability, we have isolated mutations in a gene we call ROT1 (requires overexpression of Tor1p). This gene is identical to DNA2,...

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Identifiers

PMID: 9398673
DOI: 10.1091/mbc.8.12.2519
PMCID: PMC25725

Genes

ATM
DNA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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