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Article

TTX resistivity of Na+ channel in newt retinal neuron.

Biochemical and biophysical research communications - 26 Nov 1997

Kaneko Y, Matsumoto G, Hanyu Y

Abstract excerpt

We examined voltage-dependent, TTX-resistant Na+ channels of newt retina (nRNaCh) electrophysiologically. IC50-TTX value of nRNaCh is more than 20 microM. We determined partial cDNA sequences of nRNaCh restricted to TTX binding sites (SS2 regions of all four repeats). While the amino acid sequences of SS2 regions of repeats II, III and IV of nRNaCh are identical to those of TTX-sensitive Na+ channels, only one...

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PMID: 9398620
DOI: 10.1006/bbrc.1997.7696

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