Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tetrodotoxin-resistant Na+ channels in human neuroblastoma cells are encoded by new variants of Nav1.5/SCN5A.

The European journal of neuroscience - 1 Aug 2005

Ou Shao-Wu, Kameyama Asako, Hao Li-Ying, Horiuchi Masahisa, Minobe Etsuko, Wang Wu-Yang, Makita Naomasa, Kameyama Masaki

Abstract excerpt

Both tetrodotoxin-sensitive (TTX-S) and TTX-resistant (TTX-R) voltage-dependent Na+ channels are expressed in the human neuroblastoma cell line NB-1, but a gene encoding the TTX-R Na+ channel has not been identified. In this study, we have cloned cDNA encoding the alpha subunit of the TTX-R Na+ channel in NB-1 cells and designated it hNbR1. The longest open reading frame of hNbR1 (accession no. AB158469) encodes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 3
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electric Stimulation

Share to Inhibitory Concentration 50

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to Neuroblastoma

Share to Sodium Channel Blockers

Share to Tetrodotoxin

Source

Identifiers

PMID: 16115203
DOI: 10.1111/j.1460-9568.2005.04280.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tetrodotoxin-resistant Na+ channels in human neuroblastoma cells are encoded by new variants of Nav1.5/SCN5A.PMID 16115203Read ↗

Voltage-gated sodium channels in the mammalian heartSemantic proximity Read ↗

Non-canonical endogenous expression of voltage-gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell lineSemantic proximity Read ↗

Investigations of the Navβ1b sodium channel subunit in human ventricle; functional characterization of the H162P Brugada syndrome mutant.Semantic proximity Read ↗

Structural basis for pore blockade of the human cardiac sodium channel Na <sub>v</sub> 1.5 by tetrodotoxin and quinidineSemantic proximity Read ↗

Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.Semantic proximity Read ↗

Molecular cloning, distribution and functional analysis of the NAV1.6. Voltage-gated sodium channel from human brainSemantic proximity Read ↗

Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cellsSemantic proximity Read ↗

Molecular and Cellular Context Influences SCN8A Variant FunctionSemantic proximity Read ↗

Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.Semantic proximity Read ↗

Expression and Pharmacology of Endogenous Cav Channels in SH-SY5Y Human Neuroblastoma CellsSemantic proximity Read ↗

Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.Semantic proximity Read ↗

Molecular and cellular context influences SCN8A variant function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.