Article
A missense mutation of the muscle glycogen synthase gene (M416V) is associated with insulin resistance in the Japanese population.
Diabetologia - 1 Aug 1997
Shimomura H, Sanke T, Ueda K, Hanabusa T, Sakagashira S, Nanjo K
Abstract excerpt
Muscle glycogen synthase (GYS1) is a key enzyme of non-oxidative pathway of glucose metabolism that has been reported to be related to insulin resistance in non-insulin-dependent diabetic (NIDDM) patients. We scanned the GYS1 gene for mutation by single strand conformational polymorphism in 244 non-obese Japanese NIDDM patients and 181 non-diabetic control subjects, and found two missense mutations; Met to Val at...
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