Article
Identification of a second Grb2 binding site in the v-Fms tyrosine kinase.
Oncogene - 25 Sept 1997
Mancini A, Niedenthal R, Joos H, Koch A, Trouliaris S, Niemann H, Tamura T
Abstract excerpt
Tyrosine autophosphorylation of the v-Fms oncogene product results in the formation of high-affinity binding sites for cellular proteins containing Src homology 2 (SH2) domains. These proteins transduce various mitogenic and morphogenic signals. As reported previously, Y696KNI in the kinase insert domain of v-Fms binds to the growth factor receptor bound protein 2 (Grb2), a stimulator of the Ras/Raf1 pathway....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.