Article
Out of balance: consequences of a partial keratin 10 knockout.
Journal of cell science - 1 Sept 1997
Reichelt J, Bauer C, Porter R, Lane E, Magin V
Abstract excerpt
Recently we generated keratin 10 knockout mice which provided a valuable model for the dominantly inherited skin disorder epidermolytic hyperkeratosis. Here we investigated the molecular basis for their phenotype. Hetero- and homozygotes expressed a truncated keratin 10 peptide which has been identified directly by microsequencing. Epitope mapping of monoclonal antibodies to keratin 10T enabled us to study its...
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