Article
Modeling the Structure of Keratin 1 and 10 Terminal Domains and their Misassembly in Keratoderma.
The Journal of investigative dermatology - 1 Sept 2017
Badowski Cedric, Sim Adelene Y L, Verma Chandra, Szeverényi Ildikó, Natesavelalar Chidambaram, Terron-Kwiatkowski Ana, Harper John, O'Toole Edel A, Lane E Birgitte
Abstract excerpt
The terminal domains of suprabasal keratins of the skin epithelium are very resistant to evidence-based structural analysis because of their inherent flexibility and lack of predictable structure. We present a model for the structure and interactions of the head and tail domains of epidermal keratins 1 and 10, based on all-atom 3D simulations of keratin primary amino acid sequences, and tyrosine phosphorylation...
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