Leucine is the most stabilizing aliphatic amino acid in the d position of a dimeric leucine zipper coiled coil.

doi:10.1021/bi971424h

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Article

Leucine is the most stabilizing aliphatic amino acid in the d position of a dimeric leucine zipper coiled coil.

Biochemistry - 14 Oct 1997

Moitra J, Szilák L, Krylov D, Vinson C

Abstract excerpt

The energetic contribution of seven amino acids in the d position of a dimeric leucine zipper coiled coil structure was measured by determining the thermal stability. The d position contains the conserved leucines found in the leucine zipper. We used a natural bZIP protein as our host-guest syste...

Topics

Amino Acid Sequence
DNA-Binding Proteins
Dimerization
Leucine Zippers
Molecular Sequence Data
Mutation
Protein Denaturation
Temperature

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