Article
Leucine is the most stabilizing aliphatic amino acid in the d position of a dimeric leucine zipper coiled coil.
Biochemistry - 14 Oct 1997
Moitra J, Szilák L, Krylov D, Vinson C
Abstract excerpt
The energetic contribution of seven amino acids in the d position of a dimeric leucine zipper coiled coil structure was measured by determining the thermal stability. The d position contains the conserved leucines found in the leucine zipper. We used a natural bZIP protein as our host-guest system that remains dimeric when a single d position is mutated. We have determined the thermal stability, monitored by...
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