Article
[Genetic alteration of lung cancer as a prognostic marker and its therapeutic implications].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Oct 1997
Mitsudomi T, Takahashi T
Abstract excerpt
Many genetic lesions found in non-small cell lung cancer (NSCLC) have been reported to be associated with a poor prognostic outcome of this disease. Such alterations include mutations of ras genes, overexpression of myc or erbB2 genes and inactivation of RB genes. Among them, the prognostic implications of the p53 gene have been most extensively studied; over 20 reports have been published. However, the...
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