Article
Sequence analysis of functional regions of homoserine dehydrogenase genes from L-lysine and L-threonine-producing mutants of Brevibacterium lactofermentum.
Bioscience, biotechnology, and biochemistry - 1 Oct 1997
Sugimoto M, Tanaka A, Suzuki T, Matsui H, Nakamori S, Takagi H
Abstract excerpt
The homoserine dehydrogenase (HD) genes from Brevibacterium lactofermentum lysine- and threonine-producing mutants were cloned, using the polymerase chain reaction, and sequenced. We found the amino acid substitutions, Val104Ile in the lysine-producing mutants in which HD may cause leaky mutation...
Topics
- Amino Acid Sequence
- Base Sequence
- Brevibacterium
- DNA, Bacterial
- Genes, Bacterial
- Homoserine Dehydrogenase
- Lysine
- Molecular Sequence Data
- Mutation
- Threonine