Article
Association of HLA-DR, DQ genotype with different beta-cell functions at IDDM diagnosis in Japanese children.
Diabetes - 1 Nov 1997
Sugihara S, Sakamaki T, Konda S, Murata A, Wataki K, Kobayashi Y, Minamitani K, Miyamoto S, Sasaki N, Niimi H
Abstract excerpt
Japanese IDDM patients have been demonstrated to have unique and different HLA associations from white patients. To elucidate the effect of HLA-associated genetic factors on the clinical heterogeneity of IDDM in Japanese people, HLA-DRB1, DQA1, and DQB1 genotypes in 88 childhood-onset Japanese IDDM patients were examined by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) or sequence-specific...
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