Article
Association of HLA-DR, DQ genotype with different beta-cell functions at IDDM diagnosis in Japanese children.
Diabetes - 1 Nov 1997
Sugihara S, Sakamaki T, Konda S, Murata A, Wataki K, Kobayashi Y, Minamitani K, Miyamoto S, Sasaki N, Niimi H
Abstract excerpt
Japanese IDDM patients have been demonstrated to have unique and different HLA associations from white patients. To elucidate the effect of HLA-associated genetic factors on the clinical heterogeneity of IDDM in Japanese people, HLA-DRB1, DQA1, and DQB1 genotypes in 88 childhood-onset Japanese ID...
Topics
- Adolescent
- Age Factors
- Age of Onset
- Autoantibodies
- Child
- Child, Preschool
- DNA Primers
- Diabetes Mellitus, Type 1
- Genotype
- Glutamate Decarboxylase
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- HLA-DR4 Antigen
- HLA-DRB1 Chains
- Humans
- Infant