Article
The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese.
Diabetes research and clinical practice - 1 Jan 2002
Mochizuki Mie, Amemiya Shin, Kobayashi Kisho, Kobayashi Koji, Ishihara Toshihide, Aya Misaki, Kato Kazuaki, Kasuga Akira, Nakazawa Shinpei
Abstract excerpt
Recently Iwata et al. reported that the polymorphism in NeuroD exon 2(Ala45Thr) was associated with adult-onset Type 1 diabetes in Japanese. Furthermore, the mutations in the NeuroD as a regulator of insulin transcription have been reported to result in Type 2 diabetes. We, therefore, aimed to clarify the role of this Ala45Thr polymorphism in the susceptibility to Type 1a, immune-mediated, diabetes of child-onset...
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