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Article

Reduction of cellular cisplatin resistance by hyperthermia—a review

1 Jan 1997

Abstract excerpt

Resistance to cisplatin (cDDP) is a major limitation to its clinical effectiveness. Review of literature data indicates that cDDP resistance is a multifactorial phenomenon. This provides an explanation why attempts to reverse or circumvent resistance using cDDP-analogues or combination therapy with modulators of specific resistance mechanisms have had limited success so far. It therefore provides a rationale to...

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PMID: 9354931
DOI: 10.3109/02656739709023545

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