Article
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ.
Pflugers Archiv : European journal of physiology - 1 Dec 2014
Camerino Giulia Maria, Bouchè Marina, De Bellis Michela, Cannone Maria, Liantonio Antonella, Musaraj Kejla, Romano Rossella, Smeriglio Piera, Madaro Luca, Giustino Arcangela, De Luca Annamaria, Desaphy Jean-François, Camerino Diana Conte, Pierno Sabata
Abstract excerpt
In skeletal muscle, the resting chloride conductance (gCl), due to the ClC-1 chloride channel, controls the sarcolemma electrical stability. Indeed, loss-of-function mutations in ClC-1 gene are responsible of myotonia congenita. The ClC-1 channel can be phosphorylated and inactivated by protein kinases C (PKC), but the relative contribution of each PKC isoforms is unknown. Here, we investigated on the role of...
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