Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.

The Journal of clinical investigation - 1 Jun 1999

Caniggia I, Grisaru-Gravnosky S, Kuliszewsky M, Post M, Lye S J

Abstract excerpt

Preeclampsia, the major cause of maternal morbidity and mortality in developed countries, is associated with abnormalities of placenta function due to shallow invasion of the maternal decidua by trophoblasts. Data suggest that TGF-beta may play a role in inhibiting trophoblast outgrowth or invasion, or both. We report that placental TGF-beta 3 expression is high in early pregnancy but falls at around 9 weeks'...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chorionic Villi
Share to Extracellular Space

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Organ Culture Techniques

Share to Pre-Eclampsia

Share to Pregnancy Trimester, First

Share to Protein Isoforms

Share to Transforming Growth Factor beta

Share to Trophoblasts

Source

Open in PubMed Open full text

Identifiers

PMID: 10377170
DOI: 10.1172/JCI6380
PMCID: PMC408387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.PMID 10377170Read ↗

Endoglin Regulates Trophoblast Differentiation along the Invasive Pathway in Human Placental Villous Explants*Semantic proximity Read ↗

Induction of TGF‐β receptor I expression in a DNA methylation‐independent manner mediated by DNMT3A downregulation is involved in early‐onset severe preeclampsiaSemantic proximity Read ↗

The in Vitro Effects of Triiodothyronine on Epidermal Growth Factor-Induced Trophoblast FunctionSemantic proximity Read ↗

Human trophoblast requires galectin-3 for cell migration and invasionSemantic proximity Read ↗

Integrin switching regulates normal trophoblast invasionSemantic proximity Read ↗

GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.Semantic proximity Read ↗

Effect of Matrigel on Human Extravillous Trophoblasts Differentiation: Modulation of Protease Pattern Gene Expression1Semantic proximity Read ↗

Silencing of Paternally Expressed Gene 10 Inhibits Trophoblast Proliferation and InvasionSemantic proximity Read ↗

Transforming Growth Factor-β (TGFβ) Receptors I/II Differentially Regulate TGFβ1 and IGF-Binding Protein-3 Mitogenic Effects in the Human PlacentaSemantic proximity Read ↗

SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasiveness and resistance to anti-invasive action of TGFbeta.Semantic proximity Read ↗

Preimplantation Factor (PIF) Promotes Human Trophoblast Invasion1Semantic proximity Read ↗

Induction of tissue inhibitor of metalloproteinase 3 gene expression during in vitro decidualization of human endometrial stromal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.