Article
Single strand breaks and mutagenesis in yeast induced by photodynamic treatment with chloroaluminum phthalocyanine.
Journal of photochemistry and photobiology. B, Biology - 1 Sept 1997
Paardekooper M, De Bruijne A W, Van Gompel A E, Verhage R A, Averbeck D, Dubbelman T M, Van den Broek P J
Abstract excerpt
Photodynamic treatment of the yeast Kluyveromyces marxianus with the sensitizer aluminum phthalocyanine results in loss of clonogenicity. In this paper the effect of this treatment on DNA of this yeast was investigated by searching for single strand breaks and forward mutations. Using the alkaline step elution technique it was found that illumination of the yeast in the presence of aluminum phthalocyanine...
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