Article
No association between the CNTF null mutation and schizophrenia or personality.
Psychiatric genetics - 1 Oct 2006
Nishiyama Jun, Tochigi Mamoru, Itoh Shin, Otowa Takeshi, Kato Chieko, Umekage Tadashi, Kohda Kazuhisa, Ebisawa Takashi, Kato Nobumasa, Sasaki Tsukasa
Abstract excerpt
The ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine that plays a critical role in neurodevelopment. On the basis of neurodevelopmental hypothesis, the CNTF gene has been a candidate locus for schizophrenia. Several studies have investigated the association between the null mutation of the gene and schizophrenia, however, with inconsistent results. In the present study, we investigated the...
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