Article
punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline.
Development (Cambridge, England) - 1 Nov 1997
Matunis E, Tran J, Gönczy P, Caldwell K, DiNardo S
Abstract excerpt
To identify regulators of stem cell lineages, we are focusing on spermatogenesis in Drosophila. In spermatogenesis, each germline stem cell divides asymmetrically, renewing itself and producing a transiently amplifying daughter, which divides four times. By screening for mutants in which daughter cells fail to stop dividing, we find that the TGF-beta signal transducers schnurri and punt are required to limit...
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