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Article

Mechanism of sulfonamide resistance in clinical isolates of Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Oct 1997

Maskell J P, Sefton A M, Hall L M

Abstract excerpt

The genetic basis of sulfonamide resistance in six clinical isolates of Streptococcus pneumoniae was demonstrated to be 3- or 6-bp duplications within sulA, the chromosomal gene encoding dihydropteroate synthase. The duplications all result in repetition of one or two amino acids in the region from Arg58 to Tyr63, close to but distinct from the sul-d mutation, a duplication previously reported in a resistant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9333035
DOI: 10.1128/AAC.41.10.2121
PMCID: PMC164080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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