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Article

Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies

15 Feb 1996

Abstract excerpt

Human erythroid malignancies (polycythemia vera [PV] and erythroleukemia) are associated with erythropoietin (Epo)-independent growth and differentiation. Missense or nonsense mutations in the Epo receptor (Epo-R) have been recently described in experimental erythroleukemia in mice and in cases of erythrocytosis in humans. To search for a similar genetic alteration in erythroleukemia and PV, we entirely sequenced...

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Identifiers

PMID: 8608241
DOI: 10.1182/blood.v87.4.1502.bloodjournal8741502

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Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignanciesPMID 8608241Read ↗

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