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Article

Induction of the angiogenic phenotype by Hox D3.

The Journal of cell biology - 6 Oct 1997

Boudreau N, Andrews C, Srebrow A, Ravanpay A, Cheresh D A

Abstract excerpt

Angiogenesis is characterized by distinct phenotypic changes in vascular endothelial cells (EC). Evidence is provided that the Hox D3 homeobox gene mediates conversion of endothelium from the resting to the angiogenic/invasive state. Stimulation of EC with basic fibroblast growth factor (bFGF) resulted in increased expression of Hox D3, integrin alphavbeta3, and the urokinase plasminogen activator (uPA). Hox D3...

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Identifiers

PMID: 9314544
DOI: 10.1083/jcb.139.1.257
PMCID: PMC2139816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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