Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The GPI-phospholipase C of Trypanosoma brucei is nonessential but influences parasitemia in mice.

The Journal of cell biology - 6 Oct 1997

Webb H, Carnall N, Vanhamme L, Rolin S, Van Den Abbeele J, Welburn S, Pays E, Carrington M

Abstract excerpt

In the mammalian host, the cell surface of Trypanosoma brucei is protected by a variant surface glycoprotein that is anchored in the plasma membrane through covalent attachment of the COOH terminus to a glycosylphosphatidylinositol. The trypanosome also contains a phospholipase C (GPI-PLC) that c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to GPI gene
Share to Glycosylphosphatidylinositols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Mutagenesis, Insertional

Share to Phenotype

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 9314532
DOI: 10.1083/jcb.139.1.103
PMCID: PMC2139819

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9314532-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The GPI-phospholipase C of Trypanosoma brucei is nonessential but influences parasitemia in mice.PMID 9314532Read ↗

Determinants of GPI-PLC localisation to the flagellum and access to GPI-anchored substrates in trypanosomes.Semantic proximity Read ↗

Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8.Semantic proximity Read ↗

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in <i>Trypanosoma brucei</i>Semantic proximity Read ↗

Mutational analysis of the variant surface glycoprotein GPI-anchor signal sequence in Trypanosoma brucei.Semantic proximity Read ↗

A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways.Semantic proximity Read ↗

GPI-anchored proteins and free GPI glycolipids of procyclic form Trypanosoma brucei are nonessential for growth, are required for colonization of the tsetse fly, and are not the only components of the surface coat.Semantic proximity Read ↗

The GPI sidechain of <i>Toxoplasma gondii</i> prevents parasite pathogenesisSemantic proximity Read ↗

VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathologySemantic proximity Read ↗

Targeting the GPI biosynthetic pathwaySemantic proximity Read ↗

Bloodstream form trypanosome plasma membrane proteins: antigenic variation and invariant antigensSemantic proximity Read ↗

Identification and Functional Analysis of Trypanosoma cruzi Genes That Encode Proteins of the Glycosylphosphatidylinositol Biosynthetic PathwaySemantic proximity Read ↗

PSSA-2, a membrane-spanning phosphoprotein of Trypanosoma brucei, is required for efficient maturation of infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.