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Article

Determinants of GPI-PLC localisation to the flagellum and access to GPI-anchored substrates in trypanosomes.

PLoS pathogens - 1 Jan 2013

Sunter Jack, Webb Helena, Carrington Mark

Abstract excerpt

In Trypanosoma brucei, glycosylphosphatidylinositol phospholipase C (GPI-PLC) is a virulence factor that releases variant surface glycoprotein (VSG) from dying cells. In live cells, GPI-PLC is localised to the plasma membrane where it is concentrated on the flagellar membrane, so activity or access must be tightly regulated as very little VSG is shed. Little is known about regulation except that acylation within...

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Identifiers

PMID: 23990786
DOI: 10.1371/journal.ppat.1003566
PMCID: PMC3749955

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Determinants of GPI-PLC localisation to the flagellum and access to GPI-anchored substrates in trypanosomes.PMID 23990786Read ↗

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