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Article

Mutations in the glutathione-gated KefC K+ efflux system of Escherichia coli that cause constitutive activation.

The Journal of biological chemistry - 3 Oct 1997

Miller S, Douglas R M, Carter P, Booth I R

Abstract excerpt

The kefC gene of Escherichia coli encodes a potassium efflux system that is gated by glutathione (GSH) and by GSH adducts. Independently isolated kefC mutations that result in spontaneous activation of the efflux system have been analyzed. Three mutations affect residues located adjacent to the conserved Rossman fold in the carboxyl-terminal domain. Two mutations lie in a sequence predicted to form a...

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Identifiers

PMID: 9312097
DOI: 10.1074/jbc.272.40.24942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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