Article
Prenatal diagnosis of beta-thalassaemia by coelocentesis.
Molecular human reproduction - 1 Aug 1997
Makrydimas G, Georgiou I, Kranas V, Zikopoulos K, Lolis D
Abstract excerpt
Coelomic fluid and placental tissue were obtained from four women undergoing termination of pregnancy at 7-9 weeks gestation for psychological reasons. All four women and their partners were known carriers of beta-thalassaemia and DNA analysis in their blood identified the mutation carried by each of them. Allelespecific polymerase chain reaction and denaturing gradient gel electrophoresis techniques were used to...
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