Article
Prenatal diagnosis of haemophilia.
Bailliere's clinical haematology - 1 Jun 1996
Ljung R C
Abstract excerpt
Prenatal diagnosis of haemophilia A or B is possible by means of chorionic villus biopsy in the first trimester which traces the mutation or informative genetic markers. If possible, direct gene analysis of the mutation is preferred. The natural starting point in haemophilia A is to ascertain whether the disease is due to inversion in the X-chromosome, which is the case in almost half of the severe cases. In...
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