Article
Detection of sickle gene by coelocentesis in early pregnancy: a new approach to prenatal diagnosis of single gene disorders.
Human reproduction (Oxford, England) - 1 May 1995
Jurkovic D, Jauniaux E, Campbell S, Mitchell M, Lees C, Layton M
Abstract excerpt
Coelomic fluid, placental tissue and maternal blood were collected at 7-10 weeks gestation from each of 58 women undergoing elective termination of pregnancy for psychological indications. In all samples, a 364 bp fragment of the human beta-globin gene spanning positions -23 to 341 was amplified....
Topics
- Amniocentesis
- Anemia, Sickle Cell
- Base Sequence
- DNA Primers
- Female
- Genotype
- Globins
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Pregnancy
- Prenatal Diagnosis