Article
Detection of sickle gene by coelocentesis in early pregnancy: a new approach to prenatal diagnosis of single gene disorders.
Human reproduction (Oxford, England) - 1 May 1995
Jurkovic D, Jauniaux E, Campbell S, Mitchell M, Lees C, Layton M
Abstract excerpt
Coelomic fluid, placental tissue and maternal blood were collected at 7-10 weeks gestation from each of 58 women undergoing elective termination of pregnancy for psychological indications. In all samples, a 364 bp fragment of the human beta-globin gene spanning positions -23 to 341 was amplified. The restriction endonuclease Ddel was used to detect the sickle mutation which abolishes its restriction site....
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