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Article

Regulation of renal EGF receptor expression is normal in Denys-Drash syndrome.

Kidney international - 1 Sept 1997

Vicanek C, Ferretti E, Goodyer C, Torban E, Moffett P, Pelletier J, Goodyer P

Abstract excerpt

In patients with Denys-Drash syndrome, mutations of the Wilms' tumor suppressor gene are associated with nephroblastomas and developmental abnormalities of the genital tract and renal glomerulus. Normally, the Wilms' tumor gene product (WT1) is expressed at high levels in visceral glomerular epithelial cells (VGEC) of the emerging fetal glomerulus. We demonstrate that WT1 could normally serve to suppress EGF...

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Source

Identifiers

PMID: 9291179
DOI: 10.1038/ki.1997.374

Genes

EGFR
EGF
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of renal EGF receptor expression is normal in Denys-Drash syndrome.PMID 9291179Read ↗

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.Semantic proximity Read ↗

Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis.Semantic proximity Read ↗

Constitutive expression of the Wilms tumor suppressor gene (WT1) in renal cell carcinomaSemantic proximity Read ↗

A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development.Semantic proximity Read ↗

Case report: WT1 exon 6 truncation mutation and ambiguous genitalia in a patient with Denys-Drash syndrome.Semantic proximity Read ↗

Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome.Semantic proximity Read ↗

Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome?Semantic proximity Read ↗

WT1 Activates a Glomerular-Specific Enhancer Identified from the Human Nephrin GeneSemantic proximity Read ↗

Analysis of WT1 target gene expression in stably transfected cell lines.Semantic proximity Read ↗

Association of partial gonadal dysgenesis, nephropathy and WT1 gene mutation without Wilms' tumor: incomplete Denys-Drash syndrome.Semantic proximity Read ↗

A WT1 exon 1 mutation in a child diagnosed with Denys-Drash syndrome.Semantic proximity Read ↗

Constitutional mutations in the WT1 gene in patients with Denys-Drash syndrome.Semantic proximity Read ↗

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