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Article

Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines.

Molecular pharmacology - 1 Feb 1994

Johnson M P, Loncharich R J, Baez M, Nelson D L

Abstract excerpt

Previous work has suggested that species differences in the structure-activity relationship for ergolines and tryptamines at the 5-hydroxytryptamine (5-HT)2A (formerly known as the 5-HT2) receptor are related to aliphatic substitution at the N1-position on the indole nucleus. The present work has confirmed these findings by examining the rat and human cloned 5-HT2A receptors. As previously found, N1-substitution...

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Identifiers

PMID: 8114677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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