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Article

Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines.

Molecular pharmacology - 1 Feb 1994

Johnson M P, Loncharich R J, Baez M, Nelson D L

Abstract excerpt

Previous work has suggested that species differences in the structure-activity relationship for ergolines and tryptamines at the 5-hydroxytryptamine (5-HT)2A (formerly known as the 5-HT2) receptor are related to aliphatic substitution at the N1-position on the indole nucleus. The present work has...

Topics

Amphetamines
Animals
Binding, Competitive
Cloning, Molecular
Ergolines
Humans
Hydrogen Bonding
Hydrolysis
Inositol Phosphates
Ketanserin
Mutation
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Serotonin

Species Specificity

Structure-Activity Relationship

Tryptamines

Source

Identifiers

PMID: 8114677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8114677-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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