Article
T-lymphocyte dependence of psoriatic pathology in human psoriatic skin grafted to SCID mice.
The Journal of investigative dermatology - 1 Sept 1997
Gilhar A, David M, Ullmann Y, Berkutski T, Kalish R S
Abstract excerpt
Considerable indirect evidence suggests that T lymphocytes have a role in the pathogenesis of psoriasis. The goal of this study was to directly test the ability of T cells to maintain psoriasis pathology. Psoriatic skin was transplanted onto SCID mice, which were then injected with autologous T c...
Topics
- Adoptive Transfer
- Animals
- Cell Transplantation
- Disease Models, Animal
- Filaggrin Proteins
- HLA-DR Antigens
- Humans
- Intercellular Adhesion Molecule-1
- Keratinocytes
- Mice
- Phenotype
- Protein Precursors
- Psoriasis
- Skin Transplantation
- Spleen
- T-Lymphocytes
- Transplantation, Heterologous