UM4D4+ (CDw60) T cells are compartmentalized into psoriatic skin and release lymphokines that induce a keratinocyte phenotype expressed in psoriatic lesions.

doi:10.1111/1523-1747.ep12484908

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Article

UM4D4+ (CDw60) T cells are compartmentalized into psoriatic skin and release lymphokines that induce a keratinocyte phenotype expressed in psoriatic lesions.

The Journal of investigative dermatology - 1 Sept 1990

Baadsgaard O, Tong P, Elder J T, Hansen E R, Ho V, Hammerberg C, Lange-Vejlsgaard G, Fox D A, Fisher G, Chan L S

Abstract excerpt

UM4D4 (CDw60), the surface molecule of a novel antigen-independent T-cell activation pathway, was found to be highly expressed on lesional psoriatic T cells. To examine whether UM4D4 represents a T-cell activation pathway for psoriatic T cells, a T-cell line was initiated from an acute skin lesion and cloned by limiting dilution. Clonality was verified by analysis of T-cell receptor gene rearrangement. All T-cell...

Topics

Antigens, CD
Antigens, Differentiation, T-Lymphocyte
Cell Adhesion Molecules
Clone Cells
HLA-DR Antigens
Humans
Intercellular Adhesion Molecule-1
Interferon-gamma
Interleukin-2
Keratinocytes

Lymphokines

Phenotype

Psoriasis

Skin

T-Lymphocytes

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