Article
Attenuation of soft-tissue sarcomas resistance to the cytotoxic action of TNF-α by restoring p53 function.
PloS one - 1 Jan 2012
Muret Jane, Hasmim Meriem, Stasik Izabela, Jalil Abdelali, Mallavialle Aude, Nanbakhsh Arash, Lacroix Ludovic, Billot Katy, Baud Véronique, Thiery Jérome, Vielh Philippe, Terrier Philippe, Wiels Joelle, Vassilev Lyubomir, Lecesne Axel, Bonvalot Sylvie, Chouaib Salem
Abstract excerpt
BACKGROUND: Isolated limb perfusion with TNF-α and melphalan is used with remarkable efficiency to treat unresectable limb sarcomas. Here we tested the ability of TNF-α to directly induce apoptosis of sarcoma cells. In addition, we investigated the impact of p53 in the regulation of such effect. METHODOLOGY/PRINCIPAL FINDINGS: We first analysed the ability of TNF-α to induce apoptosis in freshly isolated tumour...
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