Article
CAG repeat analyses in frozen and formalin-fixed tissues following primer extension preamplification for evaluation of mitotic instability of expanded SCA1 alleles.
Human genetics - 1 Sept 1997
Zühlke C, Hellenbroich Y, Schaaff F, Gehlken U, Wessel K, Schubert T, Cervos-Navarro J, Pickartz H, Schwinger E
Abstract excerpt
Neurodegenerative disorders, including spin-ocerebellar ataxias (SCA), Huntington disease (HD) and dentatorubral-pallidoluysian atrophy (DRPLA), are associated with unstable CAG repeats. To investigate the mitotic stability of the repetitive element in the genes for SCA1, SCA3, HD, and DRPLA we extracted DNA from up to 13 tissue samples from four deceased individuals with progressive neurological disorders and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.