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Article

Mutational analyses support a model for the HRV2 2A proteinase.

Virology - 4 Aug 1997

Sommergruber W, Seipelt J, Fessl F, Skern T, Liebig H D, Casari G

Abstract excerpt

The proteinase 2A of human rhinovirus 2 is a cysteine proteinase which contains a tightly bound Zn ion thought to be required for structural integrity. A three-dimensional model for human rhinovirus type 2 proteinase 2A (HRV2 2A) was established using sequence alignments with small trypsin-like Ser-proteinases and, for certain regions, elastase. The model was tested by expressing selected proteinase 2A mutants in...

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Identifiers

PMID: 9268151
DOI: 10.1006/viro.1997.8595

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