Article
High-resolution physical and transcriptional mapping of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy locus on chromosome 21q22.3 by FISH.
Genome research - 1 Aug 1997
Aaltonen J, Horelli-Kuitunen N, Fan J B, Björses P, Perheentupa J, Myers R, Palotie A, Peltonen L
Abstract excerpt
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, PGD type I) is an autosomal recessive disease enriched in the Finnish population. Previously, we have assigned APECED to a 2.6-cM interval on chromosome 21q22.3 by linkage analysis in 14 Finnish families. This subtelomeric re...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Cloning, Molecular
- Cosmids
- DNA
- DNA, Complementary
- Exons
- Female
- Finland
- Gene Expression
- Genetic Markers
- Genomic Library
- Genotype
- Haplotypes
- Humans