Article
AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers.
Human molecular genetics - 1 Feb 1999
Rinderle C, Christensen H M, Schweiger S, Lehrach H, Yaspo M L
Abstract excerpt
The gene responsible for autoimmune polyendocrino-pathy candidiasis ectodermal dystrophy (APECED) recently has been positionally cloned to 21q22.3. This novel gene, AIRE, encodes for a predicted 57.7 kDa protein featuring two PHD-type zinc fingers shared by other proteins involved in chromatin-me...
Topics
- Animals
- Blotting, Western
- COS Cells
- Cell Nucleus
- Cytoplasm
- Cytoskeleton
- DNA, Complementary
- Fluorescent Antibody Technique, Indirect
- Gene Expression
- Humans
- Jurkat Cells
- Mutation
- Nuclear Proteins
- Recombinant Fusion Proteins
- Transcription Factors
- Tumor Cells, Cultured
- Zinc Fingers
- AIRE Protein