Article
Centromeric inactivation in a dicentric human Y;21 translocation chromosome.
Chromosoma - 1 Sept 1997
Fisher A M, Al-Gazali L, Pramathan T, Quaife R, Cockwell A E, Barber J C, Earnshaw W C, Axelman J, Migeon B R, Tyler-Smith C
Abstract excerpt
A de novo dicentric Y;21 (q11.23;p11) translocation chromosome with one of its two centromeres inactive has provided the opportunity to study the relationship between centromeric inactivation, the organization of alphoid satellite DNA and the distribution of CENP-C. The proband, a male with minor...
Topics
- Adolescent
- Centromere
- Chromosomal Proteins, Non-Histone
- Chromosomes, Human, Pair 21
- Clone Cells
- Cytogenetics
- DNA, Satellite
- Down Syndrome
- Humans
- In Situ Hybridization, Fluorescence
- Male
- Phenotype
- Translocation, Genetic
- Y Chromosome